TRUST THE SCIENCE

We Don't Just Say “Science-Backed.” We Show You the Science.

Saffron has been valued for centuries — but tradition alone isn't why it caught our attention.

What interested us was the growing body of human clinical research investigating saffron across areas including mood, emotional well-being, stress, and women's wellness.

We believe you should be able to see that evidence for yourself.

Below are several of the published human studies that helped make saffron an ingredient worth paying attention to.

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96% REACHED DEPRESSION REMISSION*

8 Weeks • Randomized • Double-Blind • Placebo-Controlled

Researchers studied saffron in breastfeeding mothers experiencing mild-to-moderate postpartum depression.

At the end of the 8-week study, 96% of participants receiving saffron met the study's remission criterion compared with 43% receiving placebo.

Study dose: 30 mg saffron/day

SOURCE

Tabeshpour J, et al. A double-blind, randomized, placebo-controlled trial of saffron stigma (Crocus sativus L.) in mothers suffering from mild-to-moderate postpartum depression. Phytomedicine. 2017;36:145–152.

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76% ACHIEVED MAJOR PMS IMPROVEMENT*

12 Weeks • Randomized • Double-Blind • Placebo-Controlled

Researchers evaluated saffron in women experiencing premenstrual syndrome.

76% of participants receiving saffron achieved at least a 50% reduction in total PMS symptom scores compared with 8% receiving placebo.

Study dose: 30 mg saffron/day

SOURCE

Agha-Hosseini M, et al. Crocus sativus L. (saffron) in the treatment of premenstrual syndrome: a double-blind, randomised and placebo-controlled trial. BJOG. 2008;115(4):515–519.

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72% ACHIEVED MEANINGFUL IMPROVEMENT*

12 Weeks • 202 Adults • Randomized • Double-Blind • Placebo-Controlled

In a 2025 clinical trial, researchers studied a standardized saffron extract in adults experiencing depressive symptoms.

Approximately 72% of participants receiving the saffron extract achieved a clinically meaningful improvement in depressive-symptom scores compared with approximately 54% receiving placebo.

Study dose: 28 mg standardized saffron extract/day

SOURCE

Lopresti AL, Smith SJ, Marx W, Díez-Municio M, Morán-Valero MI. An Examination into the Effects of a Saffron Extract (Affron) on Mood and General Wellbeing in Adults Experiencing Low Mood: A Randomized, Double-Blind, Placebo-Controlled Trial. The Journal of Nutrition. 2025;155(7):2300–2311.

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33% REDUCTION IN ANXIETY SCORES*

12 Weeks • Randomized • Double-Blind • Placebo-Controlled

Researchers evaluated a standardized saffron extract in perimenopausal women.

Over 12 weeks, anxiety scores decreased 33% from baseline among participants receiving the saffron extract.

Researchers also reported a 32% reduction in depression scores from baseline and significantly greater improvement in psychological symptoms compared with placebo.

Study dose: 28 mg standardized saffron extract/day

SOURCE

Lopresti AL, et al. The Effects of a Saffron Extract (affron®) on Menopausal Symptoms in Women during Perimenopause: A Randomised, Double-Blind, Placebo-Controlled Study. Journal of Menopausal Medicine. 2021.

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THE BIGGER PICTURE

It's Not About One Study.

Individual clinical trials can be interesting.

A broader body of evidence matters more.

A 2019 systematic review and meta-analysis examined 23 randomized controlled trials investigating saffron supplementation across depressive and anxiety symptoms.

The researchers reported significant effects favoring saffron over placebo on both depressive and anxiety symptom measures.

They also identified limitations in the existing evidence, including publication bias, and called for continued high-quality research.

SOURCE

Marx W, et al. Effect of saffron supplementation on symptoms of depression and anxiety: a systematic review and meta-analysis. Nutrition Reviews. 2019;77(8):557–571.

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WHAT ABOUT OUR 88.5 MG?

Milligrams Don't Tell the Whole Story.

Wild & Flourish Saffron Extract provides:

88.5 mg

SAFFRON EXTRACT PER SERVING

0.3%

SAFRANAL STANDARDIZATION

3

SIMPLE INGREDIENTS

The clinical studies above used different saffron preparations and doses, including several standardized extracts studied at approximately 28–30 mg per day.

That does not mean our 88.5 mg serving is “3X stronger.”

Different saffron extracts can vary in their concentration, composition, and standardization, which makes comparing them by milligrams alone misleading.

We believe transparency is more important than turning a bigger number into a bigger marketing claim.

That's why we clearly tell you how much saffron extract is in every serving and how our extract is standardized.

As we continue documenting the specifications and testing behind our particular extract, we'll make that information available here too.

SCIENCE DESERVES CONTEXT

Here's What These Studies Do and Don't Tell Us.

The research on this page includes independent studies involving saffron and specific standardized saffron extracts.

These studies were not conducted using Wild & Flourish Saffron Extract.

The saffron preparations, dosages, study populations, durations, and outcome measures varied between studies.

We share this research because it helps explain why saffron caught our attention — not because every person taking our product should expect the same results reported in a clinical trial.

Research continues to evolve, and individual results vary.

We think you deserve to see both the findings and the context behind them.

OUR APPROACH

We read the research.

We question the claims.

We pay attention to what was actually studied — not just the headline.

And as new evidence emerges, we'll continue evaluating it.

Because when we say we're interested in evidence-informed wellness, we think you should be able to check the evidence for yourself.

We don't expect you to trust the science because we tell you to.

We'd rather show it to you.

EXPLORE OUR SAFFRON EXTRACT →